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Assay Detail

CHEMBL4723488

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of envelope protein in HCoV-229E infected in human MRC-5 cells assessed as reduction in viral replication incubated for 6 days by crystal violet staining based plaque reduction assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Human coronavirus 229E
Cell Type MRC5
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Druggable targets from coronaviruses for designing new antiviral drugs.
Silva LR,da Silva Santos-Júnior PF,de Andrade Brandão J,Anderson L,Bassi ÊJ,Xavier de Araújo-Júnior J,Cardoso SH,da Silva-Júnior EF
Bioorg Med Chem (2020) 28 : 115745 -115745
PubMed 33007557 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 1 5.87 5.87

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL501701 N,N-HEXAMETHYLENEAMILORIDE 1 5.87

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL501701 N,N-HEXAMETHYLENEAMILORIDE EC50 = 1340.0 nM 5.87