Assay Detail
Binding
CHEMBL4723752
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to N-terminal His-tagged STK17B kinase domain (25 to 329 residues) (unknown origin) expressed in Escherichia coli by KINOMEscan scanMAX assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 7.64 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1836719 | — | — | 1 | 8.42 |
| CHEMBL4752776 | — | — | 1 | 8.25 |
| CHEMBL1836721 | — | — | 1 | 7.96 |
| CHEMBL1836641 | — | — | 1 | 7.52 |
| CHEMBL4763392 | — | — | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1836719 | — | Kd | = | 3.8 | nM | 8.42 |
| CHEMBL4752776 | — | Kd | = | 5.6 | nM | 8.25 |
| CHEMBL1836721 | — | Kd | = | 11.0 | nM | 7.96 |
| CHEMBL1836641 | — | Kd | = | 30.0 | nM | 7.52 |
| CHEMBL4763392 | — | Kd | = | 910.0 | nM | 6.04 |