Assay Detail
Binding
CHEMBL4723758
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Binding affinity to C-terminal nano-luciferase tagged STK17B (unknown origin) expressed in HEK293 cells incubated for 2 hrs by nano-BRET assay based cellular target engagement assay
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 6.20 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4794509 | — | — | 1 | 6.92 |
| CHEMBL4752776 | — | — | 1 | 6.72 |
| CHEMBL1836719 | — | — | 1 | 6.68 |
| CHEMBL4755086 | — | — | 1 | 6.51 |
| CHEMBL4788024 | — | — | 1 | 6.47 |
| CHEMBL4753625 | — | — | 1 | 6.42 |
| CHEMBL4788686 | — | — | 1 | 6.30 |
| CHEMBL4789685 | — | — | 1 | 6.30 |
| CHEMBL4754748 | — | — | 1 | 6.28 |
| CHEMBL4739879 | — | — | 1 | 6.28 |
| CHEMBL4748440 | — | — | 1 | 6.26 |
| CHEMBL4792541 | — | — | 1 | 6.19 |
| CHEMBL1836714 | — | — | 1 | 6.17 |
| CHEMBL4763132 | — | — | 1 | 6.16 |
| CHEMBL4753926 | — | — | 1 | 6.14 |
| CHEMBL4748561 | — | — | 1 | 6.09 |
| CHEMBL4783516 | — | — | 1 | 6.06 |
| CHEMBL4745018 | — | — | 1 | 6.01 |
| CHEMBL4788886 | — | — | 1 | 5.92 |
| CHEMBL4760126 | — | — | 1 | 5.82 |
| CHEMBL4752999 | — | — | 1 | 5.77 |
| CHEMBL4781408 | — | — | 1 | 5.54 |
| CHEMBL1836717 | — | — | 1 | 5.50 |
| CHEMBL4756902 | — | — | 1 | - |
| CHEMBL4763392 | — | — | 1 | - |
| CHEMBL4740090 | — | — | 1 | - |
| CHEMBL4782453 | — | — | 1 | - |
| CHEMBL4761540 | — | — | 1 | - |
| CHEMBL1836637 | — | — | 1 | - |
| CHEMBL4745289 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4794509 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4752776 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1836719 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4755086 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4788024 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4753625 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4788686 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4789685 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4754748 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4739879 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4748440 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4792541 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL1836714 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL4763132 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4753926 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL4748561 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL4783516 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL4745018 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL4788886 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4760126 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4752999 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4781408 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL1836717 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4799235 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4753500 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4793795 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4759004 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1836724 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4740604 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4747753 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4796519 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4794226 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4754574 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4763345 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4745289 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1836637 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4761540 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4782453 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4740090 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4763392 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4756902 | — | IC50 | > | 10000.0 | nM | - |