Assay Detail
ADMET
CHEMBL4723828
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Chlorocebus sabaeus |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
N-(Pyrimidin-2-yl)-1,2,3,4-tetrahydroisoquinolin-6-amine Derivatives as Selective Janus Kinase 2 Inhibitors for the Treatment of Myeloproliferative Neoplasms.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.60 | 5.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4759953 | — | — | 1 | 5.98 |
| CHEMBL4754856 | — | — | 1 | 5.63 |
| CHEMBL4789273 | — | — | 1 | 5.61 |
| CHEMBL4753549 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4759953 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL4754856 | — | IC50 | = | 2330.0 | nM | 5.63 |
| CHEMBL4789273 | — | IC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL4753549 | — | IC50 | = | 6750.0 | nM | 5.17 |