Assay Detail
ADMET
CHEMBL4723830
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Cytotoxicity against human L02 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | L02 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
N-(Pyrimidin-2-yl)-1,2,3,4-tetrahydroisoquinolin-6-amine Derivatives as Selective Janus Kinase 2 Inhibitors for the Treatment of Myeloproliferative Neoplasms.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.56 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4754856 | — | — | 1 | 5.82 |
| CHEMBL4789273 | — | — | 1 | 5.69 |
| CHEMBL4759953 | — | — | 1 | 5.58 |
| CHEMBL4753549 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4754856 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL4789273 | — | IC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL4759953 | — | IC50 | = | 2660.0 | nM | 5.58 |
| CHEMBL4753549 | — | IC50 | = | 7220.0 | nM | 5.14 |