Assay Detail
Binding
CHEMBL4723928
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human sGC expressed in HUVEC cells assessed as reduction in GMP level incubated for 24 hrs by ELISA
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Soluble Guanylate Cyclase Inhibitors Discovered among Natural Compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.57 | 4.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1354529 | VIOLASTYRENE | — | 1 | 4.80 |
| CHEMBL4782639 | — | — | 1 | 4.54 |
| CHEMBL173530 | STICTIC ACID | — | 1 | 4.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1354529 | VIOLASTYRENE | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL4782639 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL173530 | STICTIC ACID | IC50 | = | 44000.0 | nM | 4.36 |