Assay Detail
Binding
CHEMBL4723932
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine lung sGC assessed as reduction in GMP level incubated for 2 hrs in presence of BAY-412272 by ELISA
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Lung |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Soluble Guanylate Cyclase Inhibitors Discovered among Natural Compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.81 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL286494 | HYPERICIN | 3.0 | 1 | 6.50 |
| CHEMBL4782639 | — | — | 1 | 5.85 |
| CHEMBL173530 | STICTIC ACID | — | 1 | 5.58 |
| CHEMBL1354529 | VIOLASTYRENE | — | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL286494 | HYPERICIN | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4782639 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL173530 | STICTIC ACID | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1354529 | VIOLASTYRENE | IC50 | = | 4900.0 | nM | 5.31 |