Assay Detail
Binding
CHEMBL4724285
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Mycobacterium tuberculosis DNA gyrase assessed as reduction in DNA supercoiled DNA formation incubated for 30 mins by SDS-PAGE analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Total Synthesis of the Antitumor-Antitubercular 2,6'-Bijuglone Natural Product Diospyrin and Its 3,6'-Isomer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.53 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 1 | 5.00 |
| CHEMBL242550 | DIOSPYRIN | — | 1 | 4.82 |
| CHEMBL241392 | NEODIOSPYRIN | — | 1 | 4.30 |
| CHEMBL1992900 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8 | CIPROFLOXACIN | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL242550 | DIOSPYRIN | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL241392 | NEODIOSPYRIN | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL1992900 | — | IC50 | = | 100000.0 | nM | 4.00 |