Assay Detail
Functional
CHEMBL4724286
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Antiproliferative activity against mouse NS-1 cells assessed as reduction in cell viability after 48 hrs by resazurin dye based assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | NS-1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Total Synthesis of the Antitumor-Antitubercular 2,6'-Bijuglone Natural Product Diospyrin and Its 3,6'-Isomer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.04 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4792519 | — | — | 1 | 6.40 |
| CHEMBL4742098 | — | — | 1 | 6.40 |
| CHEMBL430853 | RAMENTACEONE | — | 1 | 6.30 |
| CHEMBL242992 | — | — | 1 | 6.10 |
| CHEMBL242550 | DIOSPYRIN | — | 1 | 6.10 |
| CHEMBL4748800 | — | — | 1 | 5.75 |
| CHEMBL4757271 | — | — | 1 | 5.70 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4792519 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4742098 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL430853 | RAMENTACEONE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL242992 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL242550 | DIOSPYRIN | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4748800 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4757271 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 2800.0 | nM | 5.55 |