Assay Detail
Functional
CHEMBL4724381
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Antiproliferative activity against human MM1.S cells assessed as reduction in cell viability after 144 hrs
26
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MM1.S |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel dual LSD1/HDAC6 inhibitors for the treatment of multiple myeloma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 26 | 7.93 | 9.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2364628 | RICOLINOSTAT | 2.0 | 1 | 9.07 |
| CHEMBL4789904 | — | — | 1 | 9.00 |
| CHEMBL4749146 | — | — | 2 | 8.70 |
| CHEMBL4741936 | — | — | 1 | 8.70 |
| CHEMBL4762346 | — | — | 1 | 8.52 |
| CHEMBL4741826 | — | — | 1 | 8.52 |
| CHEMBL4790127 | — | — | 1 | 8.22 |
| CHEMBL4777609 | — | — | 1 | 8.15 |
| CHEMBL4780262 | — | — | 1 | 7.96 |
| CHEMBL4746111 | — | — | 1 | 7.75 |
| CHEMBL4796905 | — | — | 1 | 7.68 |
| CHEMBL4797928 | — | — | 1 | 7.62 |
| CHEMBL4777594 | — | — | 1 | 7.62 |
| CHEMBL4750725 | — | — | 1 | 7.60 |
| CHEMBL4750898 | — | — | 1 | 7.55 |
| CHEMBL4785144 | — | — | 1 | 7.48 |
| CHEMBL4791396 | — | — | 1 | 7.42 |
| CHEMBL4747062 | — | — | 1 | 7.32 |
| CHEMBL4744667 | — | — | 1 | 7.22 |
| CHEMBL4798455 | — | — | 1 | 7.20 |
| CHEMBL4763662 | — | — | 1 | 6.72 |
| CHEMBL4799143 | — | — | 1 | - |
| CHEMBL4778137 | — | — | 1 | - |
| CHEMBL4760352 | — | — | 1 | - |
| CHEMBL4782844 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2364628 | RICOLINOSTAT | EC50 | = | 0.85 | nM | 9.07 |
| CHEMBL4789904 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4749146 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4741936 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4762346 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4741826 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4749146 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4790127 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4777609 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4780262 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4746111 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4796905 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4797928 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4777594 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4750725 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4750898 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4785144 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4791396 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4747062 | — | EC50 | = | 48.0 | nM | 7.32 |
| CHEMBL4744667 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4798455 | — | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL4763662 | — | EC50 | = | 189.0 | nM | 6.72 |
| CHEMBL4799143 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4778137 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4760352 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4782844 | — | EC50 | > | 10000.0 | nM | - |