Assay Detail
Binding
CHEMBL4724649
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Inhibition of JNK1 (unknown origin) using ATF2 as substrate after 22 mins in presence of ATP by HTRF assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Thiophene-Pyrazolourea Derivatives as Potent, Orally Bioavailable, and Isoform-Selective JNK3 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.39 | 6.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4784095 | — | — | 1 | 6.14 |
| CHEMBL4753310 | — | — | 1 | 5.82 |
| CHEMBL4744992 | — | — | 1 | 5.82 |
| CHEMBL4762965 | — | — | 1 | 5.72 |
| CHEMBL4754584 | — | — | 1 | 5.66 |
| CHEMBL4755895 | — | — | 1 | 5.66 |
| CHEMBL4758113 | — | — | 1 | 5.48 |
| CHEMBL4783382 | — | — | 1 | 5.44 |
| CHEMBL4759538 | — | — | 1 | 5.38 |
| CHEMBL4778645 | — | — | 1 | 5.31 |
| CHEMBL4799926 | — | — | 1 | 5.29 |
| CHEMBL4745961 | — | — | 1 | 5.29 |
| CHEMBL4754031 | — | — | 1 | 5.24 |
| CHEMBL4753641 | — | — | 1 | 5.23 |
| CHEMBL4758690 | — | — | 1 | 5.23 |
| CHEMBL4788258 | — | — | 1 | 5.18 |
| CHEMBL4749547 | — | — | 1 | 5.14 |
| CHEMBL4793809 | — | — | 1 | 5.13 |
| CHEMBL4784092 | — | — | 1 | 5.08 |
| CHEMBL4798047 | — | — | 1 | 5.04 |
| CHEMBL4753218 | — | — | 1 | 4.99 |
| CHEMBL4754908 | — | — | 1 | - |
| CHEMBL4791169 | — | — | 1 | - |
| CHEMBL4744126 | — | — | 1 | - |
| CHEMBL4757583 | — | — | 1 | - |
| CHEMBL4777114 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4784095 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL4753310 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4744992 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4762965 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4754584 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4755895 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4758113 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4783382 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4759538 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4778645 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4799926 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4745961 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4754031 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL4753641 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4758690 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4788258 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL4749547 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL4793809 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL4784092 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL4798047 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL4753218 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL4754908 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4791169 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4744126 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4757583 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4777114 | — | IC50 | > | 20000.0 | nM | - |