Assay Detail
Binding
CHEMBL4724677
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat recombinant FTase expressed in Escherichia coli using 3H-FPP and biotinylated-DESGPGCMSCKCVLS peptide as substrates incubated for 30 mins in presence of 5 mM thiosulfate by scintillation proximity assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of an Anion-Dependent Farnesyltransferase Inhibitor from a Phenotypic Screen.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.49 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279433 | L-778123 FREE BASE | 1.0 | 1 | 7.30 |
| CHEMBL4758112 | — | — | 1 | 5.68 |
| CHEMBL4759194 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279433 | L-778123 FREE BASE | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4758112 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4759194 | — | IC50 | > | 40000.0 | nM | - |