Assay Detail
Functional
CHEMBL4724764
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against Plasmodium falciparum NF54 assessed as inhibition of parasite growth incubated for 48 hrs by [3H]hypoxanthine incorporation assay based liquid scintillation counting method
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Quest for a potent antimalarial drug lead: Synthesis and evaluation of 6,7-dimethoxyquinazoline-2,4-diamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 7.65 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4747010 | — | — | 1 | 9.40 |
| CHEMBL4780826 | — | — | 1 | 8.85 |
| CHEMBL4752262 | — | — | 1 | 8.74 |
| CHEMBL4747451 | — | — | 1 | 8.68 |
| CHEMBL4789365 | — | — | 1 | 8.66 |
| CHEMBL4788690 | — | — | 1 | 8.55 |
| CHEMBL4746538 | — | — | 1 | 8.54 |
| CHEMBL4754279 | — | — | 1 | 8.51 |
| CHEMBL4751257 | — | — | 1 | 8.50 |
| CHEMBL4757745 | — | — | 1 | 8.26 |
| CHEMBL4794593 | — | — | 1 | 8.25 |
| CHEMBL4741232 | — | — | 1 | 8.21 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 8.20 |
| CHEMBL4785276 | — | — | 1 | 8.14 |
| CHEMBL4783797 | — | — | 1 | 8.14 |
| CHEMBL4753386 | — | — | 1 | 8.09 |
| CHEMBL4781248 | — | — | 1 | 8.00 |
| CHEMBL4743520 | — | — | 1 | 7.96 |
| CHEMBL4800507 | — | — | 1 | 7.89 |
| CHEMBL4759412 | — | — | 1 | 7.87 |
| CHEMBL4776655 | — | — | 1 | 7.83 |
| CHEMBL4744748 | — | — | 1 | 7.83 |
| CHEMBL4751811 | — | — | 1 | 7.77 |
| CHEMBL4791436 | — | — | 1 | 7.72 |
| CHEMBL4764680 | — | — | 1 | 7.69 |
| CHEMBL4761755 | — | — | 1 | 7.65 |
| CHEMBL4751007 | — | — | 1 | 7.64 |
| CHEMBL4794155 | — | — | 1 | 7.59 |
| CHEMBL4750321 | — | — | 1 | 7.56 |
| CHEMBL4762822 | — | — | 1 | 7.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4747010 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4780826 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4752262 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4747451 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL4789365 | — | IC50 | = | 2.17 | nM | 8.66 |
| CHEMBL4788690 | — | IC50 | = | 2.83 | nM | 8.55 |
| CHEMBL4746538 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4754279 | — | IC50 | = | 3.07 | nM | 8.51 |
| CHEMBL4751257 | — | IC50 | = | 3.14 | nM | 8.50 |
| CHEMBL4757745 | — | IC50 | = | 5.49 | nM | 8.26 |
| CHEMBL4794593 | — | IC50 | = | 5.67 | nM | 8.25 |
| CHEMBL4741232 | — | IC50 | = | 6.14 | nM | 8.21 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 6.25 | nM | 8.20 |
| CHEMBL4785276 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL4783797 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL4753386 | — | IC50 | = | 8.16 | nM | 8.09 |
| CHEMBL4781248 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4743520 | — | IC50 | = | 10.9 | nM | 7.96 |
| CHEMBL4800507 | — | IC50 | = | 12.8 | nM | 7.89 |
| CHEMBL4759412 | — | IC50 | = | 13.6 | nM | 7.87 |
| CHEMBL4776655 | — | IC50 | = | 14.8 | nM | 7.83 |
| CHEMBL4744748 | — | IC50 | = | 14.7 | nM | 7.83 |
| CHEMBL4751811 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4791436 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4764680 | — | IC50 | = | 20.6 | nM | 7.69 |
| CHEMBL4761755 | — | IC50 | = | 22.6 | nM | 7.65 |
| CHEMBL4751007 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4794155 | — | IC50 | = | 25.4 | nM | 7.59 |
| CHEMBL4750321 | — | IC50 | = | 27.6 | nM | 7.56 |
| CHEMBL4762822 | — | IC50 | = | 30.9 | nM | 7.51 |
| CHEMBL4749901 | — | IC50 | = | 32.9 | nM | 7.48 |
| CHEMBL4758495 | — | IC50 | = | 47.1 | nM | 7.33 |
| CHEMBL4757611 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL4757453 | — | IC50 | = | 51.77 | nM | 7.29 |
| CHEMBL1824449 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL532994 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4759271 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL4785100 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL4799082 | — | IC50 | = | 4710.0 | nM | 5.33 |
| CHEMBL4780666 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL4757516 | — | IC50 | = | 34800.0 | nM | 4.46 |