Assay Detail
Binding
CHEMBL4725002
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Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction in [14C]-AMG uptake
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of remogliflozin etabonate: A potent and highly selective SGLT2 inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.20 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3950588 | — | — | 1 | 8.41 |
| CHEMBL3908950 | — | — | 1 | 8.31 |
| CHEMBL3907970 | — | — | 1 | 8.06 |
| CHEMBL3960449 | — | — | 1 | 8.00 |
| CHEMBL3923809 | — | — | 1 | 7.97 |
| CHEMBL3896936 | — | — | 1 | 7.91 |
| CHEMBL3934976 | — | — | 1 | 7.91 |
| CHEMBL3915296 | — | — | 1 | 7.81 |
| CHEMBL3980689 | — | — | 1 | 7.79 |
| CHEMBL3969998 | — | — | 1 | 7.79 |
| CHEMBL3958686 | REMOGLIFLOZIN | -1.0 | 1 | 7.74 |
| CHEMBL4786882 | — | — | 1 | 7.36 |
| CHEMBL3972664 | — | — | 1 | 7.29 |
| CHEMBL4787524 | — | — | 1 | 7.18 |
| CHEMBL4765036 | — | — | 1 | 7.07 |
| CHEMBL4785821 | — | — | 1 | 6.96 |
| CHEMBL4795938 | — | — | 1 | 6.81 |
| CHEMBL4793115 | — | — | 1 | 6.74 |
| CHEMBL4752053 | — | — | 1 | 6.12 |
| CHEMBL4750405 | — | — | 1 | 6.04 |
| CHEMBL2028665 | REMOGLIFLOZIN ETABONATE | 2.0 | 1 | 5.60 |
| CHEMBL4791676 | — | — | 1 | 5.40 |
| CHEMBL4790263 | — | — | 1 | 5.28 |
| CHEMBL4760667 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3950588 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL3908950 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL3907970 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL3960449 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3923809 | — | IC50 | = | 10.8 | nM | 7.97 |
| CHEMBL3896936 | — | IC50 | = | 12.2 | nM | 7.91 |
| CHEMBL3934976 | — | IC50 | = | 12.3 | nM | 7.91 |
| CHEMBL3915296 | — | IC50 | = | 15.4 | nM | 7.81 |
| CHEMBL3980689 | — | IC50 | = | 16.3 | nM | 7.79 |
| CHEMBL3969998 | — | IC50 | = | 16.2 | nM | 7.79 |
| CHEMBL3958686 | REMOGLIFLOZIN | IC50 | = | 18.4 | nM | 7.74 |
| CHEMBL4786882 | — | IC50 | = | 43.4 | nM | 7.36 |
| CHEMBL3972664 | — | IC50 | = | 51.2 | nM | 7.29 |
| CHEMBL4787524 | — | IC50 | = | 66.1 | nM | 7.18 |
| CHEMBL4765036 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL4785821 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4795938 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL4793115 | — | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL4752053 | — | IC50 | = | 757.0 | nM | 6.12 |
| CHEMBL4750405 | — | IC50 | = | 914.0 | nM | 6.04 |
| CHEMBL2028665 | REMOGLIFLOZIN ETABONATE | IC50 | = | 2530.0 | nM | 5.60 |
| CHEMBL4791676 | — | IC50 | = | 3950.0 | nM | 5.40 |
| CHEMBL4790263 | — | IC50 | = | 5290.0 | nM | 5.28 |
| CHEMBL4760667 | — | IC50 | > | 1000.0 | nM | - |