Assay Detail
Binding
CHEMBL4725003
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Inhibition of human SGLT1 expressed in COS7 cells assessed as reduction in [14C]-AMG uptake
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of remogliflozin etabonate: A potent and highly selective SGLT2 inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.78 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3980689 | — | — | 1 | 6.96 |
| CHEMBL4765036 | — | — | 1 | 6.82 |
| CHEMBL3950588 | — | — | 1 | 6.63 |
| CHEMBL3896936 | — | — | 1 | 6.49 |
| CHEMBL3907970 | — | — | 1 | 6.46 |
| CHEMBL3972664 | — | — | 1 | 6.42 |
| CHEMBL3908950 | — | — | 1 | 6.39 |
| CHEMBL4795938 | — | — | 1 | 6.33 |
| CHEMBL3934976 | — | — | 1 | 6.20 |
| CHEMBL3923809 | — | — | 1 | 5.99 |
| CHEMBL4793115 | — | — | 1 | 5.88 |
| CHEMBL4750405 | — | — | 1 | 5.79 |
| CHEMBL3915296 | — | — | 1 | 5.79 |
| CHEMBL3969998 | — | — | 1 | 5.77 |
| CHEMBL3960449 | — | — | 1 | 5.56 |
| CHEMBL4752053 | — | — | 1 | 5.06 |
| CHEMBL4787524 | — | — | 1 | 4.99 |
| CHEMBL4786882 | — | — | 1 | 4.88 |
| CHEMBL4785821 | — | — | 1 | 4.87 |
| CHEMBL3958686 | REMOGLIFLOZIN | -1.0 | 1 | 4.78 |
| CHEMBL4791676 | — | — | 1 | 4.62 |
| CHEMBL4790263 | — | — | 1 | 4.50 |
| CHEMBL2028665 | REMOGLIFLOZIN ETABONATE | 2.0 | 1 | - |
| CHEMBL4760667 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3980689 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL4765036 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3950588 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL3896936 | — | IC50 | = | 321.0 | nM | 6.49 |
| CHEMBL3907970 | — | IC50 | = | 345.0 | nM | 6.46 |
| CHEMBL3972664 | — | IC50 | = | 378.0 | nM | 6.42 |
| CHEMBL3908950 | — | IC50 | = | 405.0 | nM | 6.39 |
| CHEMBL4795938 | — | IC50 | = | 468.0 | nM | 6.33 |
| CHEMBL3934976 | — | IC50 | = | 626.0 | nM | 6.20 |
| CHEMBL3923809 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL4793115 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL4750405 | — | IC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL3915296 | — | IC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL3969998 | — | IC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL3960449 | — | IC50 | = | 2780.0 | nM | 5.56 |
| CHEMBL4752053 | — | IC50 | = | 8710.0 | nM | 5.06 |
| CHEMBL4787524 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL4786882 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL4785821 | — | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL3958686 | REMOGLIFLOZIN | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL4791676 | — | IC50 | = | 23700.0 | nM | 4.62 |
| CHEMBL4790263 | — | IC50 | = | 31500.0 | nM | 4.50 |
| CHEMBL2028665 | REMOGLIFLOZIN ETABONATE | IC50 | > | 100000.0 | nM | - |
| CHEMBL4760667 | — | IC50 | > | 100000.0 | nM | - |