Assay Detail
Binding
CHEMBL4725184
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IDO1 in IFN-gamma/LPS induced human whole blood assessed as tryptophan/kynurenine level measured after 18 hrs by RapidFire mass spectrometry
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Imidazopyridines as Potent Inhibitors of Indoleamine 2,3-Dioxygenase 1 for Cancer Immunotherapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.52 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4750659 | — | — | 1 | 8.22 |
| CHEMBL4750211 | — | — | 1 | 8.05 |
| CHEMBL4746203 | — | — | 1 | 7.85 |
| CHEMBL4752094 | — | — | 1 | 7.80 |
| CHEMBL4756822 | — | — | 1 | 7.68 |
| CHEMBL4779097 | — | — | 1 | 7.58 |
| CHEMBL4796040 | — | — | 1 | 7.51 |
| CHEMBL4755937 | — | — | 1 | 7.50 |
| CHEMBL4743245 | — | — | 1 | 7.44 |
| CHEMBL4763467 | — | — | 1 | 7.30 |
| CHEMBL4761987 | — | — | 1 | 7.02 |
| CHEMBL4757655 | — | — | 1 | 6.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4750659 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4750211 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4746203 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4752094 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4756822 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4779097 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4796040 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4755937 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4743245 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4763467 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4761987 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL4757655 | — | IC50 | = | 459.0 | nM | 6.34 |