Assay Detail
Binding
CHEMBL4725185
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Transactivation of PXR (unknown origin) assessed as CYP450 induction
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nuclear receptor subfamily 1 group I member 2 (CHEMBL3401) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Imidazopyridines as Potent Inhibitors of Indoleamine 2,3-Dioxygenase 1 for Cancer Immunotherapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.84 | 6.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4746203 | — | — | 1 | 6.26 |
| CHEMBL4752094 | — | — | 1 | 6.03 |
| CHEMBL4763467 | — | — | 1 | 5.97 |
| CHEMBL4756822 | — | — | 1 | 5.92 |
| CHEMBL4796040 | — | — | 1 | 5.52 |
| CHEMBL4761987 | — | — | 1 | 5.32 |
| CHEMBL4757655 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4746203 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4752094 | — | EC50 | = | 940.0 | nM | 6.03 |
| CHEMBL4763467 | — | EC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL4756822 | — | EC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL4796040 | — | EC50 | = | 3030.0 | nM | 5.52 |
| CHEMBL4761987 | — | EC50 | = | 4820.0 | nM | 5.32 |
| CHEMBL4757655 | — | EC50 | > | 50000.0 | nM | - |