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Assay Detail

CHEMBL4725210

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Functional
Induction of proliferation of human T eff cells by T cell/DC mixed lymphocyte reaction (MLR) assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type T cell
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Discovery of Imidazopyridines as Potent Inhibitors of Indoleamine 2,3-Dioxygenase 1 for Cancer Immunotherapy.
Zhang L,Cherney EC,Zhu X,Lin TA,Gullo-Brown J,Maley D,Johnston-Allegretto K,Kopcho L,Fereshteh M,Huang C,Li X,Traeger SC,Dhar G,Anandam A,Mahankali S,Padmanabhan S,Rajanna P,Murali V,Mariappan T,Borzilleri R,Vite G,Hunt JT,Balog A
ACS Med Chem Lett (2021) 12 : 494 -501
PubMed 33738077 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 1 8.70 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4161733 1 8.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4161733 EC50 = 2.0 nM 8.70