Assay Detail
Binding
CHEMBL4725691
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Inhibition of PDE4 in human U937 cell lysate using cAMP as substrate by LANCE assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Subcellular | Lysate |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Advances in the Development of Phosphodiesterase-4 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.80 | 10.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3113974 | TRANIMILAST | 2.0 | 1 | 10.59 |
| CHEMBL4778407 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3113974 | TRANIMILAST | IC50 | = | 0.026 | nM | 10.59 |
| CHEMBL4778407 | — | IC50 | = | 100.0 | nM | 7.00 |