Assay Detail
Functional
CHEMBL4725865
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiinflammatory activity in human neutrophils assessed as inhibition of fMLF/cytochalasin B-induced superoxide anion generation preincubated for 5 mins followed by fMLF addition after priming with CB for 3 mins by spectrophotometric analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Neutrophil |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Anti-inflammatory principles from Lindera aggregata.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.35 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44 | GENISTEIN | 2.0 | 1 | 5.96 |
| CHEMBL462880 | ISOBOLDINE | — | 1 | 5.24 |
| CHEMBL4743650 | — | — | 1 | 5.13 |
| CHEMBL464099 | — | — | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44 | GENISTEIN | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL462880 | ISOBOLDINE | IC50 | = | 5810.0 | nM | 5.24 |
| CHEMBL4743650 | — | IC50 | = | 7450.0 | nM | 5.13 |
| CHEMBL464099 | — | IC50 | = | 8360.0 | nM | 5.08 |