Assay Detail
Binding
CHEMBL4725952
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to wild type HIV1 integrase G140S/Q148H mutant
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and SAR study of bridged tricyclic pyrimidinone carboxamides as HIV-1 integrase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 7.94 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4786078 | — | — | 1 | 8.10 |
| CHEMBL4779601 | — | — | 1 | 7.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4786078 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL4779601 | — | Ki | = | 17.0 | nM | 7.77 |