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Assay Detail

CHEMBL4726172

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative against human DEL/BVR cells incubated for 96 hrs by cellTiter-Glo assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type DEL/BVR
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Structure-activity relationships of tubulysin analogues.
Courter JR,Hamilton JZ,Hendrick NR,Zaval M,Waight AB,Lyon RP,Senter PD,Jeffrey SC,Burke PJ
Bioorg Med Chem Lett (2020) 30 : 127241 -127241
PubMed 32527543 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 17 7.75 9.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4764573 1 9.40
CHEMBL4790483 1 9.00
CHEMBL4788265 1 9.00
CHEMBL4797389 1 8.70
CHEMBL4793061 1 8.70
CHEMBL4776169 1 8.40
CHEMBL4763090 1 8.22
CHEMBL4776260 1 7.82
CHEMBL4747384 1 7.77
CHEMBL4753668 1 7.21
CHEMBL4792574 1 7.18
CHEMBL4798076 1 7.18
CHEMBL4798639 1 7.05
CHEMBL4746178 1 6.91
CHEMBL4793054 1 6.38
CHEMBL4795686 1 5.02
CHEMBL4787870 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4764573 EC50 = 0.4 nM 9.40
CHEMBL4790483 EC50 = 1.0 nM 9.00
CHEMBL4788265 EC50 = 1.0 nM 9.00
CHEMBL4797389 EC50 = 2.0 nM 8.70
CHEMBL4793061 EC50 = 2.0 nM 8.70
CHEMBL4776169 EC50 = 4.0 nM 8.40
CHEMBL4763090 EC50 = 6.0 nM 8.22
CHEMBL4776260 EC50 = 15.0 nM 7.82
CHEMBL4747384 EC50 = 17.0 nM 7.77
CHEMBL4753668 EC50 = 61.0 nM 7.21
CHEMBL4792574 EC50 = 66.0 nM 7.18
CHEMBL4798076 EC50 = 66.0 nM 7.18
CHEMBL4798639 EC50 = 89.0 nM 7.05
CHEMBL4746178 EC50 = 123.0 nM 6.91
CHEMBL4793054 EC50 = 420.0 nM 6.38
CHEMBL4795686 EC50 = 9600.0 nM 5.02
CHEMBL4787870 EC50 - -