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Assay Detail

CHEMBL4726246

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Newcastle disease virus neuraminidase using 4-MUNeu5Ac as substrate incubated for 15 mins by spectrofluorometric analysis
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Avian orthoavulavirus 1
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

2β-3,4-Unsaturated sialic acid derivatives: Synthesis optimization, and biological evaluation as Newcastle disease virus hemagglutinin-neuraminidase inhibitors.
La Rocca P,Rota P,Piccoli M,Cirillo F,Ghiroldi A,Franco V,Allevi P,Anastasia L
Bioorg Med Chem (2020) 28 : 115563 -115563
PubMed 32616179 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.92 6.78

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4794921 1 6.78
CHEMBL4300492 1 6.75
CHEMBL4756138 1 6.72
CHEMBL4753314 1 6.67
CHEMBL4745230 1 5.61
CHEMBL96712 NEU5AC2EN 1 4.89
CHEMBL4751929 1 4.00
CHEMBL4792054 1 -
CHEMBL4779317 1 -
CHEMBL4761516 1 -
CHEMBL4746115 1 -
CHEMBL4764169 1 -
CHEMBL4753409 1 -
CHEMBL4743493 1 -
CHEMBL4744597 1 -
CHEMBL4750824 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4794921 IC50 = 166.0 nM 6.78
CHEMBL4300492 IC50 = 178.0 nM 6.75
CHEMBL4756138 IC50 = 191.0 nM 6.72
CHEMBL4753314 IC50 = 213.0 nM 6.67
CHEMBL4745230 IC50 = 2450.0 nM 5.61
CHEMBL96712 NEU5AC2EN IC50 = 13000.0 nM 4.89
CHEMBL4751929 IC50 = 100000.0 nM 4.00
CHEMBL4792054 IC50 > 1000000.0 nM -
CHEMBL4779317 IC50 = 384000.0 nM -
CHEMBL4761516 IC50 = 512000.0 nM -
CHEMBL4746115 IC50 = 148000.0 nM -
CHEMBL4764169 IC50 = 485000.0 nM -
CHEMBL4753409 IC50 = 248000.0 nM -
CHEMBL4743493 IC50 = 406000.0 nM -
CHEMBL4744597 IC50 > 1000000.0 nM -
CHEMBL4750824 IC50 = 511000.0 nM -