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Assay Detail

CHEMBL4726301

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of rat liver ST6Gal-1 using p-nitrophenyl-DL-alanine measured up to 20 mins by HPLC analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Beta-galactoside alpha-2,6-sialyltransferase 1 (CHEMBL4276)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Design, synthesis and evaluation of carbamate-linked uridyl-based inhibitors of human ST6Gal I.
Montgomery AP,Dobie C,Szabo R,Hallam L,Ranson M,Yu H,Skropeta D
Bioorg Med Chem (2020) 28 : 115561 -115561
PubMed 32616185 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 7.16 7.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4102509 1 7.16

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4102509 Ki = 70.0 nM 7.16