Assay Detail
Binding
CHEMBL4726660
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of beta lactamase VIM-2 in Pseudomonas aeruginosa 3015473 in presence of nitrocefin as reporter substrate measured after 5 mins by microplate spectrophotometry analysis
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pseudomonas aeruginosa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structural studies of triazole inhibitors with promising inhibitor effects against antibiotic resistance metallo-β-lactamases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.77 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4788033 | — | — | 1 | 7.17 |
| CHEMBL4793717 | — | — | 1 | 6.92 |
| CHEMBL4750008 | — | — | 1 | 6.80 |
| CHEMBL4796446 | — | — | 1 | 6.64 |
| CHEMBL4748654 | — | — | 1 | 6.28 |
| CHEMBL4743887 | — | — | 1 | 5.82 |
| CHEMBL4741814 | — | — | 1 | 5.64 |
| CHEMBL4782105 | — | — | 1 | 5.14 |
| CHEMBL584206 | — | — | 1 | 4.82 |
| CHEMBL4760439 | — | — | 1 | 4.68 |
| CHEMBL4759266 | — | — | 1 | 4.64 |
| CHEMBL4753298 | — | — | 1 | 4.64 |
| CHEMBL4782956 | — | — | 1 | - |
| CHEMBL4745925 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4788033 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL4793717 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4750008 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4796446 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4748654 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4743887 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4741814 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4782105 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL584206 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4760439 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL4759266 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL4753298 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL4782956 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL4745925 | — | IC50 | - | — | - |