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Assay Detail

CHEMBL4727124

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition human BACE1 expressed in baculovirus expression system using Panvera peptide as substrate measured after 60 mins by fluorescence assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Beta-secretase 1 (CHEMBL4822)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6.
Pérez-Areales FJ,Garrido M,Aso E,Bartolini M,De Simone A,Espargaró A,Ginex T,Sabate R,Pérez B,Andrisano V,Puigoriol-Illamola D,Pallàs M,Luque FJ,Loza MI,Brea J,Ferrer I,Ciruela F,Messeguer A,Muñoz-Torrero D
J Med Chem (2020) 63 : 9360 -9390
PubMed 32706255 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 4.97 5.14

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4789620 1 5.14
CHEMBL4747836 1 5.08
CHEMBL4747041 1 4.90
CHEMBL4789172 1 4.75
CHEMBL4797814 1 -
CHEMBL4758624 1 -
CHEMBL4762419 1 -
CHEMBL4794645 1 -
CHEMBL4796461 1 -
CHEMBL4794549 1 -
CHEMBL4792460 1 -
CHEMBL4749077 1 -
CHEMBL4755403 1 -
CHEMBL4747354 1 -
CHEMBL4796696 1 -
CHEMBL4798535 1 -
CHEMBL292314 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4789620 IC50 = 7190.0 nM 5.14
CHEMBL4747836 IC50 = 8310.0 nM 5.08
CHEMBL4747041 IC50 = 12500.0 nM 4.90
CHEMBL4789172 IC50 = 18000.0 nM 4.75
CHEMBL4797814 IC50 - -
CHEMBL4758624 IC50 - -
CHEMBL4762419 IC50 - -
CHEMBL4794645 IC50 - -
CHEMBL4796461 IC50 - -
CHEMBL4794549 IC50 - -
CHEMBL4792460 IC50 - -
CHEMBL4749077 IC50 - -
CHEMBL4755403 IC50 - -
CHEMBL4747354 IC50 - -
CHEMBL4796696 IC50 - -
CHEMBL4798535 IC50 - -
CHEMBL292314 IC50 - -