Assay Detail
Binding
CHEMBL4727489
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Antagonist activity at TLR9 in human PBMC assessed as inhibition of ODN2216-induced IFNalpha production
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of potent, orally bioavailable in vivo efficacious antagonists of the TLR7/8 pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.58 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4634860 | — | — | 1 | 6.00 |
| CHEMBL4796453 | — | — | 1 | 5.92 |
| CHEMBL4783510 | — | — | 1 | 5.85 |
| CHEMBL4782200 | — | — | 1 | 5.66 |
| CHEMBL4755173 | — | — | 1 | 5.64 |
| CHEMBL4748638 | — | — | 1 | 5.57 |
| CHEMBL4790219 | — | — | 1 | 5.48 |
| CHEMBL4776103 | — | — | 1 | 5.47 |
| CHEMBL4792072 | — | — | 1 | 5.47 |
| CHEMBL4740820 | — | — | 1 | 5.43 |
| CHEMBL4745239 | — | — | 1 | 5.28 |
| CHEMBL4761527 | — | — | 1 | 5.19 |
| CHEMBL4740968 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4634860 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4796453 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4783510 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4782200 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4755173 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4748638 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4790219 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4776103 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4792072 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4740820 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL4745239 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL4761527 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL4740968 | — | IC50 | > | 5000.0 | nM | - |