Assay Detail
Functional
CHEMBL4727520
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of 2-indolinone derivatives as PAK1 inhibitors in MDA-MB-231 cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.04 | 5.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3609327 | — | — | 1 | 5.38 |
| CHEMBL4777980 | — | — | 1 | 5.32 |
| CHEMBL4748052 | — | — | 1 | 5.21 |
| CHEMBL4779121 | — | — | 1 | 5.20 |
| CHEMBL4761779 | — | — | 1 | 5.15 |
| CHEMBL4747190 | — | — | 1 | 5.10 |
| CHEMBL4741943 | — | — | 1 | 5.08 |
| CHEMBL4743541 | — | — | 1 | 5.04 |
| CHEMBL4761972 | — | — | 1 | 5.04 |
| CHEMBL4779460 | — | — | 1 | 5.01 |
| CHEMBL4799887 | — | — | 1 | 4.99 |
| CHEMBL4784170 | — | — | 1 | 4.98 |
| CHEMBL4764030 | — | — | 1 | 4.96 |
| CHEMBL4755550 | — | — | 1 | 4.92 |
| CHEMBL4791897 | — | — | 1 | 4.88 |
| CHEMBL4743990 | — | — | 1 | 4.72 |
| CHEMBL4741285 | — | — | 1 | 4.71 |
| CHEMBL4747628 | — | — | 1 | - |
| CHEMBL4747878 | — | — | 1 | - |
| CHEMBL4791784 | — | — | 1 | - |
| CHEMBL4793325 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3609327 | — | IC50 | = | 4160.0 | nM | 5.38 |
| CHEMBL4777980 | — | IC50 | = | 4810.0 | nM | 5.32 |
| CHEMBL4748052 | — | IC50 | = | 6210.0 | nM | 5.21 |
| CHEMBL4779121 | — | IC50 | = | 6330.0 | nM | 5.20 |
| CHEMBL4761779 | — | IC50 | = | 7050.0 | nM | 5.15 |
| CHEMBL4747190 | — | IC50 | = | 7870.0 | nM | 5.10 |
| CHEMBL4741943 | — | IC50 | = | 8240.0 | nM | 5.08 |
| CHEMBL4743541 | — | IC50 | = | 9010.0 | nM | 5.04 |
| CHEMBL4761972 | — | IC50 | = | 9130.0 | nM | 5.04 |
| CHEMBL4779460 | — | IC50 | = | 9720.0 | nM | 5.01 |
| CHEMBL4799887 | — | IC50 | = | 10330.0 | nM | 4.99 |
| CHEMBL4784170 | — | IC50 | = | 10490.0 | nM | 4.98 |
| CHEMBL4764030 | — | IC50 | = | 11040.0 | nM | 4.96 |
| CHEMBL4755550 | — | IC50 | = | 12070.0 | nM | 4.92 |
| CHEMBL4791897 | — | IC50 | = | 13050.0 | nM | 4.88 |
| CHEMBL4743990 | — | IC50 | = | 19110.0 | nM | 4.72 |
| CHEMBL4741285 | — | IC50 | = | 19380.0 | nM | 4.71 |
| CHEMBL4747628 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4747878 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4791784 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4793325 | — | IC50 | > | 25000.0 | nM | - |