Assay Detail
Binding
CHEMBL4727754
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ALK2 R206H mutant using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery, synthesis and characterization of a series of 7-aryl-imidazo[1,2-a]pyridine-3-ylquinolines as activin-like kinase (ALK) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.24 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4740381 | — | — | 1 | 8.42 |
| CHEMBL4788859 | — | — | 1 | 8.25 |
| CHEMBL4786529 | — | — | 1 | 8.06 |
| CHEMBL4742906 | — | — | 1 | - |
| CHEMBL4778971 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4740381 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL4788859 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL4786529 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL4742906 | — | IC50 | < | 5.0 | nM | - |
| CHEMBL4778971 | — | IC50 | < | 5.0 | nM | - |