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Assay Detail

CHEMBL4728095

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of electric eel AChE by Ellman's method
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Electrophorus electricus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Acetylcholinesterase (CHEMBL4078)
Type SINGLE PROTEIN
Organism Electrophorus electricus

Publication

New coumarin-benzotriazole based hybrid molecules as inhibitors of acetylcholinesterase and amyloid aggregation.
Singh A,Sharma S,Arora S,Attri S,Kaur P,Kaur Gulati H,Bhagat K,Kumar N,Singh H,Vir Singh J,Mohinder Singh Bedi P
Bioorg Med Chem Lett (2020) 30 : 127477 -127477
PubMed 32781220 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 31 5.84 7.41

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL502 DONEPEZIL 4.0 1 7.41
CHEMBL4749763 1 7.23
CHEMBL4762795 1 7.01
CHEMBL4756123 1 6.63
CHEMBL4750478 1 5.94
CHEMBL4758921 1 5.94
CHEMBL4741410 1 5.93
CHEMBL4755707 1 5.88
CHEMBL4764253 1 5.78
CHEMBL4778639 1 5.72
CHEMBL4782518 1 5.70
CHEMBL4782774 1 5.70
CHEMBL4761822 1 5.68
CHEMBL4758696 1 5.67
CHEMBL4758084 1 5.53
CHEMBL4753776 1 5.49
CHEMBL4778582 1 5.36
CHEMBL4747633 1 5.36
CHEMBL4761402 1 5.32
CHEMBL4781507 1 5.27
CHEMBL4784930 1 5.26
CHEMBL4796953 1 5.26
CHEMBL4798200 1 5.21
CHEMBL4746553 1 -
CHEMBL4762724 1 -
CHEMBL4754009 1 -
CHEMBL4777793 1 -
CHEMBL4757272 1 -
CHEMBL4788572 1 -
CHEMBL4743747 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL502 DONEPEZIL IC50 = 39.0 nM 7.41
CHEMBL4749763 IC50 = 59.0 nM 7.23
CHEMBL4762795 IC50 = 97.0 nM 7.01
CHEMBL4756123 IC50 = 234.0 nM 6.63
CHEMBL4750478 IC50 = 1156.0 nM 5.94
CHEMBL4758921 IC50 = 1141.0 nM 5.94
CHEMBL4741410 IC50 = 1176.0 nM 5.93
CHEMBL4755707 IC50 = 1324.0 nM 5.88
CHEMBL4764253 IC50 = 1670.0 nM 5.78
CHEMBL4778639 IC50 = 1890.0 nM 5.72
CHEMBL4782518 IC50 = 2012.0 nM 5.70
CHEMBL4782774 IC50 = 1978.0 nM 5.70
CHEMBL4761822 IC50 = 2093.0 nM 5.68
CHEMBL4758696 IC50 = 2112.0 nM 5.67
CHEMBL4758084 IC50 = 2924.0 nM 5.53
CHEMBL4753776 IC50 = 3233.0 nM 5.49
CHEMBL4778582 IC50 = 4322.0 nM 5.36
CHEMBL4747633 IC50 = 4329.0 nM 5.36
CHEMBL4761402 IC50 = 4810.0 nM 5.32
CHEMBL4781507 IC50 = 5422.0 nM 5.27
CHEMBL4784930 IC50 = 5429.0 nM 5.26
CHEMBL4796953 IC50 = 5436.0 nM 5.26
CHEMBL4798200 IC50 = 6233.0 nM 5.21
CHEMBL4746553 IC50 >= 10000.0 nM -
CHEMBL4762724 IC50 >= 10000.0 nM -
CHEMBL4754009 IC50 >= 10000.0 nM -
CHEMBL4777793 IC50 >= 10000.0 nM -
CHEMBL4757272 IC50 >= 10000.0 nM -
CHEMBL4788572 IC50 >= 10000.0 nM -
CHEMBL4743747 IC50 >= 10000.0 nM -
CHEMBL4791291 IC50 >= 10000.0 nM -