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Assay Detail

CHEMBL4728098

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Mixed type inhibition of electric eel AChE assessed as inhibition constant using varying levels of acetylthiocholine as substrate by reciprocal Lineweaver-Burk plot analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Electrophorus electricus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Acetylcholinesterase (CHEMBL4078)
Type SINGLE PROTEIN
Organism Electrophorus electricus

Publication

New coumarin-benzotriazole based hybrid molecules as inhibitors of acetylcholinesterase and amyloid aggregation.
Singh A,Sharma S,Arora S,Attri S,Kaur P,Kaur Gulati H,Bhagat K,Kumar N,Singh H,Vir Singh J,Mohinder Singh Bedi P
Bioorg Med Chem Lett (2020) 30 : 127477 -127477
PubMed 32781220 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 10.38 10.38

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4749763 1 10.38

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4749763 Ki = 0.04167 nM 10.38