Assay Detail
Binding
CHEMBL4728534
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Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins followed by substrate addition and measured at 30 secs interval for 10 mins by fluorescence assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2-Oxaadamant-1-yl Ureas as Soluble Epoxide Hydrolase Inhibitors: In Vivo Evaluation in a Murine Model of Acute Pancreatitis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.06 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL242459 | — | — | 1 | 9.30 |
| CHEMBL1818385 | — | — | 1 | 8.11 |
| CHEMBL436774 | AR9281 | 2.0 | 1 | 8.10 |
| CHEMBL4779073 | — | — | 1 | 8.05 |
| CHEMBL4778324 | — | — | 1 | 7.71 |
| CHEMBL4797443 | — | — | 1 | 7.67 |
| CHEMBL4759592 | — | — | 1 | 7.52 |
| CHEMBL4750570 | — | — | 1 | 7.45 |
| CHEMBL4784603 | — | — | 1 | 7.34 |
| CHEMBL4762265 | — | — | 1 | 7.28 |
| CHEMBL4753341 | — | — | 1 | 7.08 |
| CHEMBL4785423 | — | — | 1 | 6.80 |
| CHEMBL4784283 | — | — | 1 | 6.71 |
| CHEMBL4800149 | — | — | 1 | 6.67 |
| CHEMBL4758083 | — | — | 1 | 6.61 |
| CHEMBL4764423 | — | — | 1 | 6.45 |
| CHEMBL4762846 | — | — | 1 | 6.31 |
| CHEMBL4746168 | — | — | 1 | 6.30 |
| CHEMBL4764141 | — | — | 1 | 6.11 |
| CHEMBL4790388 | — | — | 1 | 6.04 |
| CHEMBL4748933 | — | — | 1 | 5.96 |
| CHEMBL4751517 | — | — | 1 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL242459 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL1818385 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL436774 | AR9281 | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4779073 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4778324 | — | IC50 | = | 19.7 | nM | 7.71 |
| CHEMBL4797443 | — | IC50 | = | 21.3 | nM | 7.67 |
| CHEMBL4759592 | — | IC50 | = | 29.9 | nM | 7.52 |
| CHEMBL4750570 | — | IC50 | = | 35.9 | nM | 7.45 |
| CHEMBL4784603 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4762265 | — | IC50 | = | 52.6 | nM | 7.28 |
| CHEMBL4753341 | — | IC50 | = | 82.5 | nM | 7.08 |
| CHEMBL4785423 | — | IC50 | = | 159.0 | nM | 6.80 |
| CHEMBL4784283 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL4800149 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL4758083 | — | IC50 | = | 247.0 | nM | 6.61 |
| CHEMBL4764423 | — | IC50 | = | 356.0 | nM | 6.45 |
| CHEMBL4762846 | — | IC50 | = | 491.0 | nM | 6.31 |
| CHEMBL4746168 | — | IC50 | = | 496.0 | nM | 6.30 |
| CHEMBL4764141 | — | IC50 | = | 782.0 | nM | 6.11 |
| CHEMBL4790388 | — | IC50 | = | 911.0 | nM | 6.04 |
| CHEMBL4748933 | — | IC50 | = | 1093.0 | nM | 5.96 |
| CHEMBL4751517 | — | IC50 | = | 1448.0 | nM | 5.84 |