Assay Detail
Binding
CHEMBL4729136
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Agonist activity at zebrafish GPR34 type a expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
6
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Danio rerio |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Non-naturally Occurring Regio Isomer of Lysophosphatidylserine Exhibits Potent Agonistic Activity toward G Protein-Coupled Receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.59 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1742484 | — | — | 2 | 6.89 |
| CHEMBL4753103 | — | — | 2 | 6.29 |
| CHEMBL4758243 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1742484 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1742484 | — | EC50 | = | 128.82 | nM | 6.89 |
| CHEMBL4753103 | — | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL4753103 | — | EC50 | = | 512.86 | nM | 6.29 |
| CHEMBL4758243 | — | EC50 | > | 3000.0 | nM | - |
| CHEMBL4758243 | — | EC50 | < | 3162.28 | nM | - |