Assay Detail
Functional
CHEMBL4729141
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Antimalarial activity against chloroquine-sensitive synchronized ring stage of Plasmodium falciparum 3D7 incubated for 48 to 52 hrs by SYBR green 1 dye based assay
31
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of Potent PfCLK3 Inhibitors Based on TCMDC-135051 as a New Class of Antimalarials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 28 | 6.08 | 7.75 |
| pEC50 | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 7.75 |
| CHEMBL4798421 | — | — | 2 | 6.75 |
| CHEMBL4749934 | — | — | 2 | 6.60 |
| CHEMBL4779045 | — | — | 2 | 6.51 |
| CHEMBL4763273 | — | — | 2 | 6.42 |
| CHEMBL4741460 | — | — | 2 | 6.34 |
| CHEMBL4783687 | — | — | 2 | 5.93 |
| CHEMBL4743985 | — | — | 2 | 5.90 |
| CHEMBL4792168 | — | — | 2 | 5.84 |
| CHEMBL531865 | — | — | 2 | 5.60 |
| CHEMBL4776343 | — | — | 2 | 5.60 |
| CHEMBL4750978 | — | — | 2 | 5.50 |
| CHEMBL4787871 | — | — | 2 | 5.50 |
| CHEMBL4783094 | — | — | 2 | - |
| CHEMBL4752340 | — | — | 2 | - |
| CHEMBL4799910 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL36 | PYRIMETHAMINE | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4798421 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4798421 | — | EC50 | = | 199.53 | nM | 6.70 |
| CHEMBL4749934 | — | EC50 | = | 251.19 | nM | 6.60 |
| CHEMBL4749934 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4779045 | — | EC50 | = | 309.0 | nM | 6.51 |
| CHEMBL4779045 | — | EC50 | = | 316.23 | nM | 6.50 |
| CHEMBL4763273 | — | EC50 | = | 382.0 | nM | 6.42 |
| CHEMBL4763273 | — | EC50 | = | 398.11 | nM | 6.40 |
| CHEMBL4741460 | — | EC50 | = | 457.0 | nM | 6.34 |
| CHEMBL4741460 | — | EC50 | = | 501.19 | nM | 6.30 |
| CHEMBL4783687 | — | EC50 | = | 1185.0 | nM | 5.93 |
| CHEMBL4743985 | — | EC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL4743985 | — | EC50 | = | 1339.0 | nM | 5.87 |
| CHEMBL4792168 | — | EC50 | = | 1456.0 | nM | 5.84 |
| CHEMBL4792168 | — | EC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL4776343 | — | EC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL4783687 | — | EC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL531865 | — | EC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL4776343 | — | EC50 | = | 2801.0 | nM | 5.55 |
| CHEMBL4750978 | — | EC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL4787871 | — | EC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL531865 | — | EC50 | = | 3167.0 | nM | 5.50 |
| CHEMBL4750978 | — | EC50 | = | 3272.0 | nM | 5.49 |
| CHEMBL4787871 | — | EC50 | = | 3529.0 | nM | 5.45 |
| CHEMBL4783094 | — | EC50 | - | — | - | |
| CHEMBL4799910 | — | EC50 | - | — | - | |
| CHEMBL4783094 | — | pEC50 | - | — | - | |
| CHEMBL4752340 | — | pEC50 | - | — | - | |
| CHEMBL4799910 | — | pEC50 | - | — | - | |
| CHEMBL4752340 | — | EC50 | - | — | - |