Assay Detail
Binding
CHEMBL4729290
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of Flu-BID/FAM-BID from His-tagged Mcl-1 (171 to 327 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells incubated for 3 hrs by fluorescence polarization assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Induced myeloid leukemia cell differentiation protein Mcl-1 (CHEMBL4361) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a Copper-Based Mcl-1 Inhibitor as an Effective Antitumor Agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 5.70 | 8.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3417704 | — | — | 1 | 8.33 |
| CHEMBL4796830 | — | — | 1 | 5.50 |
| CHEMBL4757050 | — | — | 1 | 5.31 |
| CHEMBL4758555 | — | — | 1 | 5.26 |
| CHEMBL4744295 | — | — | 1 | 5.21 |
| CHEMBL4778579 | — | — | 1 | 5.18 |
| CHEMBL4794980 | — | — | 1 | 5.10 |
| CHEMBL4578154 | — | — | 1 | - |
| CHEMBL4743955 | — | — | 1 | - |
| CHEMBL4777267 | — | — | 1 | - |
| CHEMBL4760810 | — | — | 1 | - |
| CHEMBL4748351 | — | — | 1 | - |
| CHEMBL4792991 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3417704 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL4796830 | — | Ki | = | 3125.4 | nM | 5.50 |
| CHEMBL4757050 | — | Ki | = | 4932.8 | nM | 5.31 |
| CHEMBL4758555 | — | Ki | = | 5519.5 | nM | 5.26 |
| CHEMBL4744295 | — | Ki | = | 6127.3 | nM | 5.21 |
| CHEMBL4778579 | — | Ki | = | 6613.8 | nM | 5.18 |
| CHEMBL4794980 | — | Ki | = | 7879.6 | nM | 5.10 |
| CHEMBL4578154 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4743955 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4777267 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4760810 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4748351 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4792991 | — | Ki | > | 10000.0 | nM | - |