Assay Detail
Binding
CHEMBL4729292
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal biotin-labeled BIM BH3 peptide (141 to 166 residues) binding to His-tagged Mcl-1 (171 to 327 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells incubated for >=30 mins by fluorescence polarization
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Induced myeloid leukemia cell differentiation protein Mcl-1 (CHEMBL4361) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a Copper-Based Mcl-1 Inhibitor as an Effective Antitumor Agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.81 | 8.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3417704 | — | — | 1 | 8.06 |
| CHEMBL4778579 | — | — | 1 | 5.07 |
| CHEMBL4796830 | — | — | 1 | 5.05 |
| CHEMBL4757050 | — | — | 1 | 5.04 |
| CHEMBL4578154 | — | — | 1 | - |
| CHEMBL4744295 | — | — | 1 | - |
| CHEMBL4758555 | — | — | 1 | - |
| CHEMBL4743955 | — | — | 1 | - |
| CHEMBL4777267 | — | — | 1 | - |
| CHEMBL4760810 | — | — | 1 | - |
| CHEMBL4794980 | — | — | 1 | - |
| CHEMBL4748351 | — | — | 1 | - |
| CHEMBL4792991 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3417704 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL4778579 | — | IC50 | = | 8523.9 | nM | 5.07 |
| CHEMBL4796830 | — | IC50 | = | 8812.3 | nM | 5.05 |
| CHEMBL4757050 | — | IC50 | = | 9082.3 | nM | 5.04 |
| CHEMBL4578154 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4744295 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4758555 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4743955 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4777267 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4760810 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4794980 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4748351 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4792991 | — | IC50 | > | 10000.0 | nM | - |