Assay Detail
Functional
CHEMBL4729295
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Cytotoxicity against human K562 cells after 24 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a Copper-Based Mcl-1 Inhibitor as an Effective Antitumor Agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.66 | 4.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3417704 | — | — | 1 | 4.86 |
| CHEMBL4796830 | — | — | 1 | 4.75 |
| CHEMBL4757050 | — | — | 1 | 4.65 |
| CHEMBL4758555 | — | — | 1 | 4.54 |
| CHEMBL4744295 | — | — | 1 | 4.48 |
| CHEMBL4578154 | — | — | 1 | - |
| CHEMBL4743955 | — | — | 1 | - |
| CHEMBL4777267 | — | — | 1 | - |
| CHEMBL4778579 | — | — | 1 | - |
| CHEMBL4760810 | — | — | 1 | - |
| CHEMBL4794980 | — | — | 1 | - |
| CHEMBL4748351 | — | — | 1 | - |
| CHEMBL4792991 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3417704 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL4796830 | — | IC50 | = | 17900.0 | nM | 4.75 |
| CHEMBL4757050 | — | IC50 | = | 22600.0 | nM | 4.65 |
| CHEMBL4758555 | — | IC50 | = | 28900.0 | nM | 4.54 |
| CHEMBL4744295 | — | IC50 | = | 32800.0 | nM | 4.48 |
| CHEMBL4578154 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4743955 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4777267 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4778579 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4760810 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4794980 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4748351 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4792991 | — | IC50 | > | 40000.0 | nM | - |