Assay Detail
Binding
CHEMBL4729414
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Inhibition of human recombinant HDAC6 using ZMAL (Z-Lys(Ac)-AMC) fluorogenic substrate incubated for 90 mins by fluorescence based assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Multicomponent Synthesis, Binding Mode, and Structure-Activity Relationship of Selective Histone Deacetylase 6 (HDAC6) Inhibitors with Bifurcated Capping Groups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.18 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2018302 | TUBASTATIN A | — | 1 | 7.85 |
| CHEMBL2364628 | RICOLINOSTAT | 2.0 | 1 | 7.70 |
| CHEMBL2179618 | NEXTURASTAT A | — | 1 | 7.70 |
| CHEMBL4800426 | — | — | 1 | 7.52 |
| CHEMBL4786332 | — | — | 1 | 7.52 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.40 |
| CHEMBL4781216 | — | — | 1 | 7.22 |
| CHEMBL4748093 | — | — | 1 | 7.16 |
| CHEMBL4740787 | — | — | 1 | 7.10 |
| CHEMBL4066043 | — | — | 1 | 7.07 |
| CHEMBL4752076 | — | — | 1 | 7.00 |
| CHEMBL4780849 | — | — | 1 | 7.00 |
| CHEMBL4754868 | — | — | 1 | 6.92 |
| CHEMBL4760090 | — | — | 1 | 6.92 |
| CHEMBL4756672 | — | — | 1 | 6.92 |
| CHEMBL4761974 | — | — | 1 | 6.50 |
| CHEMBL4754795 | — | — | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2018302 | TUBASTATIN A | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2364628 | RICOLINOSTAT | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2179618 | NEXTURASTAT A | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4800426 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4786332 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4781216 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4748093 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4740787 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4066043 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL4752076 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4780849 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4754868 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4760090 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4756672 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4761974 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4754795 | — | IC50 | = | 330.0 | nM | 6.48 |