Assay Detail
Binding
CHEMBL4729423
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Selectivity index, ratio of IC50 for inhibition of human recombinant HDAC8 to IC50 for inhibition of human recombinant HDAC6
2
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Multicomponent Synthesis, Binding Mode, and Structure-Activity Relationship of Selective Histone Deacetylase 6 (HDAC6) Inhibitors with Bifurcated Capping Groups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ratio IC50 | 1 | - | - |
| IC50 | 1 | 6.46 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4456445 | — | — | 1 | 6.46 |
| CHEMBL4800426 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4456445 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4800426 | — | Ratio IC50 | = | 490.0 | — | - |