Assay Detail
Binding
CHEMBL4729565
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Inhibition of HDAC1 (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Rational Design of Suprastat: A Novel Selective Histone Deacetylase 6 Inhibitor with the Ability to Potentiate Immunotherapy in Melanoma Models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.63 | 6.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3935992 | — | — | 1 | 6.11 |
| CHEMBL4783802 | — | — | 1 | 5.95 |
| CHEMBL4469488 | — | — | 1 | 5.86 |
| CHEMBL4761969 | — | — | 1 | 5.16 |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3935992 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL4783802 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL4469488 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL4761969 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL2018302 | TUBASTATIN A | IC50 | = | 8100.0 | nM | 5.09 |