Assay Detail
Functional
CHEMBL4729691
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Antiproliferative activity against wild-type human U251 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-251 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Dimeric small molecule agonists of EphA2 receptor inhibit glioblastoma cell growth.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 4.90 | 5.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4796707 | — | — | 1 | 5.59 |
| CHEMBL4800258 | — | — | 1 | 5.52 |
| CHEMBL4170029 | — | — | 1 | 5.28 |
| CHEMBL4763314 | — | — | 1 | 5.13 |
| CHEMBL4743476 | — | — | 1 | 5.10 |
| CHEMBL4782528 | — | — | 1 | 5.09 |
| CHEMBL4780785 | — | — | 1 | 5.09 |
| CHEMBL4784904 | — | — | 1 | 5.08 |
| CHEMBL4764123 | — | — | 1 | 5.05 |
| CHEMBL188679 | — | — | 1 | 5.05 |
| CHEMBL4760980 | — | — | 1 | 5.04 |
| CHEMBL4797934 | — | — | 1 | 5.00 |
| CHEMBL4763068 | — | — | 1 | 4.97 |
| CHEMBL4785494 | — | — | 1 | 4.93 |
| CHEMBL366103 | — | — | 1 | 4.91 |
| CHEMBL4757701 | — | — | 1 | 4.90 |
| CHEMBL4168909 | — | — | 1 | 4.83 |
| CHEMBL4791067 | — | — | 1 | 4.78 |
| CHEMBL4743448 | — | — | 1 | 4.75 |
| CHEMBL4800241 | — | — | 1 | 4.61 |
| CHEMBL4759706 | — | — | 1 | 4.45 |
| CHEMBL4788996 | — | — | 1 | 4.34 |
| CHEMBL4795916 | — | — | 1 | 4.32 |
| CHEMBL4752577 | — | — | 1 | 4.32 |
| CHEMBL4788507 | — | — | 1 | 4.28 |
| CHEMBL4778844 | — | — | 1 | - |
| CHEMBL4758535 | — | — | 1 | - |
| CHEMBL4758346 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4796707 | — | IC50 | = | 2590.0 | nM | 5.59 |
| CHEMBL4800258 | — | IC50 | = | 3050.0 | nM | 5.52 |
| CHEMBL4170029 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL4763314 | — | IC50 | = | 7480.0 | nM | 5.13 |
| CHEMBL4743476 | — | IC50 | = | 7910.0 | nM | 5.10 |
| CHEMBL4782528 | — | IC50 | = | 8070.0 | nM | 5.09 |
| CHEMBL4780785 | — | IC50 | = | 8110.0 | nM | 5.09 |
| CHEMBL4784904 | — | IC50 | = | 8340.0 | nM | 5.08 |
| CHEMBL4764123 | — | IC50 | = | 8840.0 | nM | 5.05 |
| CHEMBL188679 | — | IC50 | = | 8980.0 | nM | 5.05 |
| CHEMBL4760980 | — | IC50 | = | 9220.0 | nM | 5.04 |
| CHEMBL4797934 | — | IC50 | = | 10120.0 | nM | 5.00 |
| CHEMBL4763068 | — | IC50 | = | 10770.0 | nM | 4.97 |
| CHEMBL4785494 | — | IC50 | = | 11690.0 | nM | 4.93 |
| CHEMBL366103 | — | IC50 | = | 12230.0 | nM | 4.91 |
| CHEMBL4757701 | — | IC50 | = | 12620.0 | nM | 4.90 |
| CHEMBL4168909 | — | IC50 | = | 14730.0 | nM | 4.83 |
| CHEMBL4791067 | — | IC50 | = | 16490.0 | nM | 4.78 |
| CHEMBL4743448 | — | IC50 | = | 17910.0 | nM | 4.75 |
| CHEMBL4800241 | — | IC50 | = | 24800.0 | nM | 4.61 |
| CHEMBL4759706 | — | IC50 | = | 35290.0 | nM | 4.45 |
| CHEMBL4788996 | — | IC50 | = | 45720.0 | nM | 4.34 |
| CHEMBL4795916 | — | IC50 | = | 47940.0 | nM | 4.32 |
| CHEMBL4752577 | — | IC50 | = | 47860.0 | nM | 4.32 |
| CHEMBL4788507 | — | IC50 | = | 53010.0 | nM | 4.28 |
| CHEMBL4778844 | — | IC50 | = | 174010.0 | nM | - |
| CHEMBL4758535 | — | IC50 | = | 128100.0 | nM | - |
| CHEMBL4758346 | — | IC50 | = | 160000.0 | nM | - |