Assay Detail
Functional
CHEMBL4730125
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferation activity against EGFR-negative human SW620 cells assessed as reduction in cell viability incubated incubated for 48 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW-620 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and SAR study of 2-aminopyrimidines with diverse Michael addition acceptors for chemically tuning the potency against EGFR.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.40 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4745868 | — | — | 1 | 5.68 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 5.67 |
| CHEMBL4789716 | — | — | 1 | 5.63 |
| CHEMBL4776012 | — | — | 1 | 5.63 |
| CHEMBL4740234 | — | — | 1 | 5.62 |
| CHEMBL4776073 | — | — | 1 | 5.52 |
| CHEMBL4794857 | — | — | 1 | 5.44 |
| CHEMBL4746377 | — | — | 1 | 5.40 |
| CHEMBL4785849 | — | — | 1 | 5.34 |
| CHEMBL3545308 | ROCILETINIB | 3.0 | 1 | 4.98 |
| CHEMBL4793105 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4745868 | — | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL4789716 | — | IC50 | = | 2330.0 | nM | 5.63 |
| CHEMBL4776012 | — | IC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL4740234 | — | IC50 | = | 2410.0 | nM | 5.62 |
| CHEMBL4776073 | — | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL4794857 | — | IC50 | = | 3610.0 | nM | 5.44 |
| CHEMBL4746377 | — | IC50 | = | 3990.0 | nM | 5.40 |
| CHEMBL4785849 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL3545308 | ROCILETINIB | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL4793105 | — | IC50 | = | 29150.0 | nM | 4.54 |