Assay Detail
Functional
CHEMBL4730199
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Antiproliferation activity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of thiapyran-pyrimidine derivatives as potential EGFR inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 4.78 | 5.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4780534 | — | — | 1 | 5.38 |
| CHEMBL3786343 | OLMUTINIB | 4.0 | 1 | 5.37 |
| CHEMBL4754481 | — | — | 1 | 5.24 |
| CHEMBL4754688 | — | — | 1 | 5.16 |
| CHEMBL4795151 | — | — | 1 | 5.09 |
| CHEMBL4740516 | — | — | 1 | 5.09 |
| CHEMBL4776833 | — | — | 1 | 5.00 |
| CHEMBL4750689 | — | — | 1 | 5.00 |
| CHEMBL4781613 | — | — | 1 | 4.97 |
| CHEMBL4788876 | — | — | 1 | 4.93 |
| CHEMBL4753063 | — | — | 1 | 4.93 |
| CHEMBL4799495 | — | — | 1 | 4.88 |
| CHEMBL4746894 | — | — | 1 | 4.84 |
| CHEMBL4750969 | — | — | 1 | 4.77 |
| CHEMBL4743860 | — | — | 1 | 4.76 |
| CHEMBL4750398 | — | — | 1 | 4.76 |
| CHEMBL4750261 | — | — | 1 | 4.73 |
| CHEMBL4742383 | — | — | 1 | 4.70 |
| CHEMBL4798859 | — | — | 1 | 4.70 |
| CHEMBL4756906 | — | — | 1 | 4.67 |
| CHEMBL4744287 | — | — | 1 | 4.65 |
| CHEMBL4756475 | — | — | 1 | 4.62 |
| CHEMBL4744312 | — | — | 1 | 4.60 |
| CHEMBL4787084 | — | — | 1 | 4.59 |
| CHEMBL4782114 | — | — | 1 | 4.57 |
| CHEMBL4757002 | — | — | 1 | 4.53 |
| CHEMBL4790984 | — | — | 1 | 4.48 |
| CHEMBL4753109 | — | — | 1 | 4.45 |
| CHEMBL4787398 | — | — | 1 | 4.43 |
| CHEMBL4799945 | — | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4780534 | — | IC50 | = | 4220.0 | nM | 5.38 |
| CHEMBL3786343 | OLMUTINIB | IC50 | = | 4290.0 | nM | 5.37 |
| CHEMBL4754481 | — | IC50 | = | 5790.0 | nM | 5.24 |
| CHEMBL4754688 | — | IC50 | = | 6860.0 | nM | 5.16 |
| CHEMBL4795151 | — | IC50 | = | 8040.0 | nM | 5.09 |
| CHEMBL4740516 | — | IC50 | = | 8190.0 | nM | 5.09 |
| CHEMBL4776833 | — | IC50 | = | 10090.0 | nM | 5.00 |
| CHEMBL4750689 | — | IC50 | = | 10110.0 | nM | 5.00 |
| CHEMBL4781613 | — | IC50 | = | 10820.0 | nM | 4.97 |
| CHEMBL4788876 | — | IC50 | = | 11870.0 | nM | 4.93 |
| CHEMBL4753063 | — | IC50 | = | 11820.0 | nM | 4.93 |
| CHEMBL4799495 | — | IC50 | = | 13110.0 | nM | 4.88 |
| CHEMBL4746894 | — | IC50 | = | 14590.0 | nM | 4.84 |
| CHEMBL4750969 | — | IC50 | = | 16830.0 | nM | 4.77 |
| CHEMBL4750398 | — | IC50 | = | 17180.0 | nM | 4.76 |
| CHEMBL4743860 | — | IC50 | = | 17230.0 | nM | 4.76 |
| CHEMBL4750261 | — | IC50 | = | 18550.0 | nM | 4.73 |
| CHEMBL4742383 | — | IC50 | = | 20110.0 | nM | 4.70 |
| CHEMBL4798859 | — | IC50 | = | 19820.0 | nM | 4.70 |
| CHEMBL4756906 | — | IC50 | = | 21140.0 | nM | 4.67 |
| CHEMBL4744287 | — | IC50 | = | 22240.0 | nM | 4.65 |
| CHEMBL4756475 | — | IC50 | = | 24230.0 | nM | 4.62 |
| CHEMBL4744312 | — | IC50 | = | 25310.0 | nM | 4.60 |
| CHEMBL4787084 | — | IC50 | = | 25910.0 | nM | 4.59 |
| CHEMBL4782114 | — | IC50 | = | 26860.0 | nM | 4.57 |
| CHEMBL4757002 | — | IC50 | = | 29640.0 | nM | 4.53 |
| CHEMBL4790984 | — | IC50 | = | 33450.0 | nM | 4.48 |
| CHEMBL4753109 | — | IC50 | = | 35910.0 | nM | 4.45 |
| CHEMBL4787398 | — | IC50 | = | 36870.0 | nM | 4.43 |
| CHEMBL4799945 | — | IC50 | = | 36810.0 | nM | 4.43 |
| CHEMBL4791980 | — | IC50 | = | 44210.0 | nM | 4.35 |
| CHEMBL4778794 | — | IC50 | = | 46890.0 | nM | 4.33 |
| CHEMBL4800351 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4798081 | — | IC50 | > | 50000.0 | nM | - |