Assay Detail
ADMET
CHEMBL4730203
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Cytotoxicity against human L02 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | L02 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of thiapyran-pyrimidine derivatives as potential EGFR inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 4.40 | 4.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3786343 | OLMUTINIB | 4.0 | 1 | 4.59 |
| CHEMBL4757002 | — | — | 1 | 4.38 |
| CHEMBL4800351 | — | — | 1 | 4.32 |
| CHEMBL4776833 | — | — | 1 | 4.31 |
| CHEMBL4750261 | — | — | 1 | - |
| CHEMBL4746894 | — | — | 1 | - |
| CHEMBL4756475 | — | — | 1 | - |
| CHEMBL4750689 | — | — | 1 | - |
| CHEMBL4754481 | — | — | 1 | - |
| CHEMBL4787398 | — | — | 1 | - |
| CHEMBL4753109 | — | — | 1 | - |
| CHEMBL4780534 | — | — | 1 | - |
| CHEMBL4744287 | — | — | 1 | - |
| CHEMBL4742383 | — | — | 1 | - |
| CHEMBL4788876 | — | — | 1 | - |
| CHEMBL4782114 | — | — | 1 | - |
| CHEMBL4787084 | — | — | 1 | - |
| CHEMBL4798081 | — | — | 1 | - |
| CHEMBL4799945 | — | — | 1 | - |
| CHEMBL4740516 | — | — | 1 | - |
| CHEMBL4791980 | — | — | 1 | - |
| CHEMBL4790984 | — | — | 1 | - |
| CHEMBL4778794 | — | — | 1 | - |
| CHEMBL4756906 | — | — | 1 | - |
| CHEMBL4743860 | — | — | 1 | - |
| CHEMBL4753063 | — | — | 1 | - |
| CHEMBL4798859 | — | — | 1 | - |
| CHEMBL4744312 | — | — | 1 | - |
| CHEMBL4750398 | — | — | 1 | - |
| CHEMBL4754688 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3786343 | OLMUTINIB | IC50 | = | 25760.0 | nM | 4.59 |
| CHEMBL4757002 | — | IC50 | = | 41230.0 | nM | 4.38 |
| CHEMBL4800351 | — | IC50 | = | 47770.0 | nM | 4.32 |
| CHEMBL4776833 | — | IC50 | = | 48940.0 | nM | 4.31 |
| CHEMBL4750689 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4750969 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4754481 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4787398 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4753109 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4780534 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4744287 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4742383 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4788876 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4782114 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4787084 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4746894 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4795151 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4799495 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4781613 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4756475 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4750261 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4798081 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4799945 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4740516 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4791980 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4790984 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4778794 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4756906 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4743860 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4753063 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4798859 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4744312 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4750398 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4754688 | — | IC50 | > | 50000.0 | nM | - |