Assay Detail
Functional
CHEMBL4730263
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Induction of IL2-stimulated human PBMC-derived Vgamma9Vdelta2 T cells proliferation using FITC-anti-human pan gamma delta TCR/PE-CD3+ antibody staining preincubated for 3 days followed by 11 days incubation post compound washout measured after 14 days by flow cytometry
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Vgamma9Vdelta2 T cell |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Potent double prodrug forms of synthetic phosphoantigens.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 8.22 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4761205 | — | — | 1 | 9.92 |
| CHEMBL4742121 | — | — | 1 | 9.09 |
| CHEMBL4790172 | — | — | 1 | 9.04 |
| CHEMBL4088948 | — | — | 1 | 8.27 |
| CHEMBL4756301 | — | — | 1 | 6.96 |
| CHEMBL4755691 | — | — | 1 | 6.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4761205 | — | EC50 | = | 0.12 | nM | 9.92 |
| CHEMBL4742121 | — | EC50 | = | 0.82 | nM | 9.09 |
| CHEMBL4790172 | — | EC50 | = | 0.92 | nM | 9.04 |
| CHEMBL4088948 | — | EC50 | = | 5.4 | nM | 8.27 |
| CHEMBL4756301 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4755691 | — | EC50 | = | 980.0 | nM | 6.01 |