Assay Detail
Functional
CHEMBL4730265
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Induction of IL2-stimulated IFNgamma production in human PBMC-derived Vgamma9Vdelta2 T cells co-cultured with compound treated human K562 cells measured after 4 mins by ELISA
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Potent double prodrug forms of synthetic phosphoantigens.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.67 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4790172 | — | — | 1 | 7.16 |
| CHEMBL4761205 | — | — | 1 | 6.14 |
| CHEMBL4742121 | — | — | 1 | 5.14 |
| CHEMBL4756301 | — | — | 1 | 4.23 |
| CHEMBL145233 | — | — | 1 | - |
| CHEMBL4755691 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4790172 | — | EC50 | = | 69.0 | nM | 7.16 |
| CHEMBL4761205 | — | EC50 | = | 730.0 | nM | 6.14 |
| CHEMBL4742121 | — | EC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL4756301 | — | EC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL145233 | — | EC50 | - | — | - | |
| CHEMBL4755691 | — | EC50 | > | 100000.0 | nM | - |