Assay Detail
Functional
CHEMBL4730614
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Antiproliferative activity against human MOLT4 cells assessed as reduction in cell viability after 48 hrs in presence of 10% human serum by CellTiter-Glo luminescent assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLT-4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of A-1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL-X Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.90 | 8.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3793424 | — | — | 1 | 8.20 |
| CHEMBL3919588 | — | — | 1 | 6.71 |
| CHEMBL3935328 | — | — | 1 | 5.79 |
| CHEMBL3912857 | — | — | 1 | - |
| CHEMBL3891330 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3793424 | — | EC50 | = | 6.3 | nM | 8.20 |
| CHEMBL3919588 | — | EC50 | = | 197.0 | nM | 6.71 |
| CHEMBL3935328 | — | EC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL3912857 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL3891330 | — | EC50 | > | 5000.0 | nM | - |