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Assay Detail

CHEMBL4730904

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to NF-kappaB RelA (unknown origin) by SPR analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Transcription factor p65 (CHEMBL5533)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Gibberellin JRA-003: A Selective Inhibitor of Nuclear Translocation of IKKα.
Annand JR,Henderson AR,Cole KS,Maurais AJ,Becerra J,Liu Y,Weerapana E,Koehler AN,Mapp AK,Schindler CS
ACS Med Chem Lett (2020) 11 : 1913 -1918
PubMed 33062173 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 2 5.05 5.20

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2359602 1 5.20
CHEMBL1232952 GIBBERELLIN A3 1 4.89

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2359602 Kd = 6340.0 nM 5.20
CHEMBL1232952 GIBBERELLIN A3 Kd = 13000.0 nM 4.89