Assay Detail
Binding
CHEMBL4731023
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Binding affinity to human A3AR assessed as inhibitor constant
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Direct Comparison of (N)-Methanocarba and Ribose-Containing 2-Arylalkynyladenosine Derivatives as A Receptor Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.95 | 9.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL574602 | — | — | 1 | 9.36 |
| CHEMBL3407784 | — | — | 1 | 9.15 |
| CHEMBL4755127 | — | — | 1 | 9.12 |
| CHEMBL431733 | NAMODENOSON | 3.0 | 1 | 8.85 |
| CHEMBL119709 | IB-MECA | — | 1 | 8.76 |
| CHEMBL2064657 | — | — | 1 | 8.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL574602 | — | Ki | = | 0.44 | nM | 9.36 |
| CHEMBL3407784 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL4755127 | — | Ki | = | 0.75 | nM | 9.12 |
| CHEMBL431733 | NAMODENOSON | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL119709 | IB-MECA | Ki | = | 1.74 | nM | 8.76 |
| CHEMBL2064657 | — | Ki | = | 3.49 | nM | 8.46 |