Assay Detail
Functional
CHEMBL4731041
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at mouse MC1R by alphascreen cAMP assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Melanocyte-stimulating hormone receptor (CHEMBL4077) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Peptoid NPhe in AGRP-Based c[Pro-Arg-Phe-Phe-Xxx-Ala-Phe-DPro] Scaffolds Maintain Mouse MC4R Antagonist Potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 6.70 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441738 | AFAMELANOTIDE | 4.0 | 1 | 11.00 |
| CHEMBL4764556 | — | — | 1 | 6.96 |
| CHEMBL4785711 | — | — | 1 | 6.62 |
| CHEMBL4785157 | — | — | 1 | 6.00 |
| CHEMBL4747952 | — | — | 1 | 5.57 |
| CHEMBL4754305 | — | — | 1 | 5.51 |
| CHEMBL4740561 | — | — | 1 | 5.25 |
| CHEMBL4797774 | — | — | 1 | - |
| CHEMBL4743564 | — | — | 1 | - |
| CHEMBL4753150 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441738 | AFAMELANOTIDE | EC50 | = | 0.01 | nM | 11.00 |
| CHEMBL4764556 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4785711 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4785157 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4747952 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4754305 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4740561 | — | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL4797774 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4743564 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4753150 | — | EC50 | > | 100000.0 | nM | - |